About
Joe joined De Novo Ventures as a Managing Director in March 2003. Prior to joining De Novo, Joe served as Chairman of Confer Software, a developer of software used to create efficiencies and streamline processes in healthcare. He also served as President/CEO of Origin Medsystems, a developer of minimally invasive surgical devices for use in general, cardio-thoracic, and ob-gyn surgery, which was acquired by Eli Lilly & Company in 1992 and spun out as one of the units which formed Guidant Corporation in 1995. At Guidant, Joe served as a member of the founding management committee and CEO of two of its five operating units, Origin and Heart Rhythm Technology. He also co-founded and served as CEO of Gynecare, a women’s health spin-out of Guidant, which was acquired by Johnson & Johnson. Subsequent to his tenure at Guidant, he served as an Entrepreneur-in-Residence at Mayfield Fund, a venture capital firm. Earlier in his career, he was CEO of Ioptex Research, a developer of intraocul
Position in the VCSift Database
- • 1,801 investors hold the Managing Director role in VCSift. Joe Mandato is one of them.
- • 7,285 investors are based in San Francisco, California, United States.
Data sourced from 410,343 investor profiles. Updated July 2026.
Investment Focus
- Stages
- seed
- Location
- San Francisco, US
Contact Information
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